Author Archives: Steve Bryson PhD

Developing Motor Neurons in SMA Show Altered Protein Production

Motor neurons derived from people with spinal muscular atrophy (SMA) showed changes in protein production at each stage of their development, from stem cells to fully mature nerve cells, a study discovered. Findings in this reported first-such study can be used to identify protein alterations that occur before the…

Potential ASO Therapy Treats SMA in Mice With Evident Symptoms

A new and noninvasive type of antisense oligonucleotide (ASO) therapy effectively treated spinal muscular atrophy (SMA) in a mouse model with established symptoms, a study reported. Since symptomatic and late-onset SMA patients are the most difficult to treat, “our [therapy] should be considered a great improvement from a clinical…

Saliva Samples Can Help Diagnose SMA, Study Demonstrates

Genetic analysis of dried saliva spots identified people with spinal muscular atrophy (SMA), a study demonstrated and possibly for the first time. The scientists noted that this noninvasive and low-cost, alternate method of genetic screening may be suitable for programs held in schools or workplaces without the need for…

New Spinraza Delivery Technique for Patients With Spinal Deformities

For spinal muscular atrophy (SMA) patients with spinal deformities, administration of Spinraza (nusinersen) by a novel subcutaneous intrathecal catheter system improved upper limb function, a small study reports. This delivery technique, however, increased the risk of mechanical malfunction and infections, the researchers noted. The study, “…

Anxiety, Depression a Problem for School-age Patients in China

School-age children and adolescents with spinal muscular atrophy (SMA) in China experience a high rate of anxiety and depression, a questionnaire-based study suggests. “Professional psychological care [may be] included in the standard of care,” the researchers wrote, noting that a higher prevalence of depression was seen among students…

Anxiety, Depression a Problem for School-aged Patients in China

School-age children and adolescents with spinal muscular atrophy (SMA) in China experience a high rate of anxiety and depression, a questionnaire-based study suggests. “Professional psychological care [may be] included in the standard of care,” the researchers wrote, noting that a higher prevalence of depression was seen among students with…