Spinal Muscular Atrophy: Caregiver Support

Spinal Muscular Atrophy: Caregiver Support

Caregivers of patients with Spinal Muscular Atrophy (SMA) report neglected aspects of their lives.1 Caregivers will need different kinds of support depending on factors such as the specific type of SMA their child has, whether they have other children, whether they...
Zolgensma

Zolgensma

In more than 95% of patients with spinal muscular atrophy (SMA), the disease is caused by a deletion in exon 7 of the Survival Motor Neuron 1 (SMN1) gene located on chromosome 5q13.1,2,3  Because the etiology of most cases of SMA can be traced back to this single...
Signs and Symptoms

Signs and Symptoms

One of the pathological hallmarks of spinal muscular atrophy (SMA) is the degeneration of anterior horn cells in the spinal cord and motor nuclei in the lower brainstem.1 Alpha motor neurons are preferentially affected, so the disease is limited to the motor system...
Prognosis

Prognosis

The disease course and prognosis of spinal muscular atrophy (SMA) depends heavily on the clinical classification in a particular patient. For example, the prognosis of children with SMA type 0 is very poor while the prognosis in SMA type 4 patients is relatively good....
What is Spinal Muscular Atrophy (SMA)?

What is Spinal Muscular Atrophy (SMA)?

  Spinal Muscular Atrophy (SMA) is a congenital neuromuscular disorder characterized most prominently by progressive muscle atrophy and weakness.1 SMA is a neurodegenrative disease and the weakness and loss of muscle tone associated with SMA are the direct result...
Spinal Muscular Atrophy: Prognosis

Spinal Muscular Atrophy: Prognosis

The disease course and prognosis of spinal muscular atrophy (SMA) depends heavily on the clinical classification in a particular patient. For example, the prognosis of children with SMA type 0 is very poor while the prognosis in SMA type 4 patients is relatively good....