Spinal Muscular Atrophy: Electromyography

Spinal Muscular Atrophy: Magnetic Resonance Imaging

Spinal Muscular Atrophy (SMA) is a progressive neuromuscular accompanied by significant typically proximal muscle weakness and atrophy due to degeneration of the anterior horn cells of the spinal cord.1  Diagnosis of SMA does not require magnetic resonance imaging...
Chest Physiotherapy and Pulmonary Care in the Acutely Ill Child

Chest Physiotherapy and Pulmonary Care in the Acutely Ill Child

Children with spinal muscular atrophy (SMA) often have difficulty with breathing and maintaining blood oxygenation in periods of relative wellness. As such, they often have limited reserve pulmonary and cardiovascular function. Thus during an acute illness, especially...
Chest Physiotherapy and Pulmonary Care in the Acutely Ill Child

Chest Physiotherapy in the Well Child

Respiratory problems are the leading cause of acute illness and chronic disability in infants and children with spinal muscular atrophy (SMA). Among children with SMA type I and type II, respiratory issues are the most common cause of death. On the other hand, when...
Nusinersen

Nusinersen

Nusinersen (Spinraza) is the first FDA-approved, disease-modifying therapy for the treatment of spinal muscular atrophy (SMA). Nusinersen is an antisense oligonucleotide that binds to a sequence downstream of exon 7 in the SMN2 gene. The oligonucleotide blocks the...